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    3. 學校概況

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      天然藥物生物制造科學中心2018年學術年會

      文章出處:學科建設辦公室  作者:  發布時間:2018-12-18


      時間:2018-12-31 (星期一)下午  地點:輕工樓A716會議室     主持人:湯亞杰教授  


      時  間

      報告人

      報 告 題 目

      14:00-15:00

      上海交通大學

      鐘建江教授

      抗癌天然產物的生物工程高產研究

      ——博士畢業后25年研究歷程之分享

      15:00-15:30

      湖北工業大學

       

      Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with  nanomolar-potency antitumor activity by improving the tubulin binding  affinity on the basis of a potential binding site nearby colchicine domain

      15:30-16:00

      湖北工業大學

       

      Phosphated or PEG structural modification of podophyllotoxin leading  compounds provide improved aqueous solubility and bioavailability in mice

      16:00-16:30

      湖北工業大學

       

      Novel antitumor leading compounds 4β-S-benzoxazole/benzothiazole-deoxy-4’-

      demethylepipodophyllotoxin display millimolar-potency toxicity on human

      heathly cells by transforming target from topoisomerase II to avoid DNA-damage

      16:30-17:00

      湖北工業大學

      姚志億

      4β-indole/Indazole podophyllotoxin, a microtubule polymerization  inhibitor, display nanomolar-potency antitumor activity in MCF-7 cells by  triggering the Microtubule-associated proteins signal cascade pathway

      17:00-17:30

      湖北工業大學

      鄭小迪

      Pharmacophore hybridization to discover candidate drugs  4β-S/NH-(indole/indazole-5-fluorobenzothiazole/5-fluorobenzoxazole)  substituted podophyllotoxin derivatives with nanomole potency activity and  millimole-potency toxicity


      時間:2019-1-1 (星期二)       地點:輕工樓A716會議室  上午     主持人:鐘建江教授


      時  間

      報告人

      報 告 題 目

      8:00-9:00

      中國海洋大學

      池振明教授

      酵母菌胞外多糖合成的研究進展

      9:00-9:30

      上海交通大學

      王平安

      CRISPR-Cas9 assisted gene editing for the  higher fungus Ganoderma lucidum

      9:30-10:00

      湖北工業大學

      賈開志

      Achieving enzymatic O-glycosylation of  etoposide aglycone by using the substrate promiscuity of glycosyltransferase

      10:00-10:30

      湖北工業大學

      劉瑞桑

      Revealing the carbon–sulfur bond biosynthesis  in thioether podophylloid derivatives

      10:30-11:00

      湖北工業大學

      劉佳飛

      Synthesis of C-NH bond substituted  podophyllotoxin derivatives by using

      imine reductases

      11:00-11:30

      湖北工業大學

       

      Carbon–sulfur bond biosynthesis in 4 position  of C-ring and hydroxyl phosphorylation of 4' position of E-ring in thioether  podophylloid derivatives

      11:30-12:00

      湖北工業大學

      張潤吉

      Genome mining with carbon–sulfur bond biosynthesis  by

      Penicillium  purpurogenum

      12:00-12:30

      湖北工業大學

      于愛琴

      Biocatalytic phosphorylation of podophylloid  derivatives

      時間:2019-1-1 (星期二) 下午  地點:輕工樓A716會議室    主持人:池振明教授


       

      報告人

      14:00-14:30

      中國海洋大學

      池哲副教授

      酵母菌鐵載體代謝工程的研究進展

      14:30-15:00

      上海交通大學

      王文方

      靈芝酸生物合成關鍵元件的挖掘

      15:00-15:30

      中國海洋大學

      姜宏博士

      沙漠酵母菌黑色素的研究進展

      15:30-16:00

      湖北工業大學

      朱麗雯

      Structural basis of target protein inhibition  by N-heterocyclic ring substituted podophyllum derivatives

      16:00-16:30

      湖北工業大學

      吳松娜

      Structural insights into the inhibition of  microtubule polymerization  by  N-heterocyclic ring substituted podophyllum derivatives with antitumor  activity

      16:30-17:00

      湖北工業大學

      趙曉民

      Structural basis of hTOP2β inhibition by the  anticancer drug 4'-demethylepipodophyllotoxin derivatives

      17:00-17:30

      湖北工業大學

      趙松垠

      Structural insights into the interaction of insulin-like  growth factor 1 receptor with podophyllum derivatives with antitumor activity

      報告題目:抗癌天然產物的生物工程高產研究——博士畢業后25年研究歷程之分享

      報 告 人:上海交通大學生命科學技術學院鐘建江教授

      報告時間20191231(星期一)下午14:00-15:00

      報告地點:輕工樓A716會議室

      主辦單位:天然藥物生物制造科學中心

      鐘建江教授,1986年畢業于華東理工大學,19901993年獲日本大阪大學發酵工程碩士和博士學位。1996年任華東理工大學教授。于2006年在上海交通大學創建了“分子生物化工與先進發酵技術研究室”,2007年至今為校特聘教授。曾獲長江學者特聘教授(1999)、國家自然科學基金杰出青年科學基金(2002)。主要從事生物工程與應用微生物學領域研究,包括生物反應器與生物過程創制,微生物代謝機理與發酵過程調控,代謝工程與合成生物學研究等。代表性研究成果包括:創建了動靜耦合發酵模式,顛覆了發酵工程傳統概念,大幅度提升了抗癌化合物靈芝酸的發酵效率;揭示了鈣信號參與靈芝酸生物合成的調控機制;建立細胞生長和次生代謝的雙重強化來定向調控次生代謝發酵的新途徑;提出了剪切力低且供氧和混合佳的反應器設計思想,創制了離心式攪拌槳生物反應器;揭示了包括植物細胞和微生物體系在內的多種次生代謝發酵過程的放大規律,為工業應用奠定重要理論基礎。近年來,在Trends in BiotechnologyBiotechnology AdvancesMetabolic EngineeringBiosensors & Bioelectronics Biotechnology & Bioengineering Applied and Environmental Microbiology 等國際主流專業期刊發表SCI 收錄論文240余篇,出版國際編著7本,據Google Scholar統計被引用11300 余次、H 指數57;獲授權國家發明專利30項。獲國家教育部自然科學一等獎(2004/2014 年度各1 次,第一完成人),湖北省自然科學一等獎 (2016 年度,第二完成人),貴州省科技進步獎一等獎 (2016 年度,第二完成人),日本生物工學會首屆“亞洲年輕生物技術學家獎”(2002 ),韓國生物技術與生物工程學會“研究交流獎”(2009 )等。受邀在重要國際學術會議做大會報告、主題報告及其他邀請報告70余次。目前兼任中國生物工程學會理事,亞洲生物技術聯合會(AFOB)顧問委員,國際期刊Process BiochemistryBiotechnology & Applied Biochemistry 主編,Biotechnology & Bioengineering Bioprocess & Biosystems Engineering 副主編,以及多個國家和省部級重點實驗室的學術委員等職。曾任華東理工大學生物反應器工程國家重點實驗室主任、AFOB秘書長、美國AIChE生物工程學會(SBE)國際顧問及多個國際學術會議主席等。

      報告題目:酵母菌胞外多糖合成的研究進展

      報 告 人:中國海洋大學海洋生命學院池振明教授

      報告時間201911(星期二)上午8:00-9:00

      報告地點:輕工樓A716會議室

      主辦單位:天然藥物生物制造科學中心

      報告人簡介:

      池振明教授, 1997年在山東大學獲得理學博士;1998年丹麥皇家農業大學完成博士后研究工作;1999-2002年山東大學微生物學教授和博士生導師;2002-至今中國海洋大學微生物學教授和博士生導師,中國海洋大學微生物學科帶頭人;中國微生物學會海洋微生物專業委員會常委。國家自然科學基金委微生物學科、國家自然科學獎生物學組和國家留學基金委評審專家。最近幾年主要從事酵母菌包括海洋酵母菌的資源、組學、代謝工程、基因編輯和發酵產物的應用基礎研究,已經發表了160多篇SCI收錄文章。

      報告題目:酵母菌鐵載體代謝工程的研究進展

      報 告 人:中國海洋大學海洋生命學院池哲副教授

      報告時間201911(星期二)下午14:00-14:30

      報告地點:輕工樓A716會議室

      主辦單位:天然藥物生物制造科學中心

      報告人簡介:

      池哲博士,中國海洋大學海洋生命學院副教授。正在主持國家自然科學基金青年科學基金項目和青島海洋科學與技術試點國家實驗室青年科學基金項目各1項。2年來以第一或通訊作者在國際知名學術期刊Critical Reviews in BiotechnologyBioresource TechnologyFood Chemistry等發表SCI論文8篇。

      報告題目:沙漠酵母菌黑色素的研究進展

      報 告 人:中國海洋大學海洋生命學院姜宏博士

      報告時間201911(星期二)下午15:00-15:30

      報告地點:輕工樓A716會議室

      主辦單位:天然藥物生物制造科學中心

      報告人簡介:

      姜宏博士,中國海洋大學海洋生命學院副教授。正在主持國家自然科學基金青年科學基金項目1項。近3年來以第一作者在國際學術期刊FoodChemistryCurrent Genetics等發表SCI論文6篇。


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